Key Takeaways
- FMC Corporation announced that HRAC classified rimisoxafen as a dual mode of action herbicide under Groups 12 and 32.
- This marks the first dual mode of action designation in HRAC’s history.
- Rimisoxafen inhibits both phytoene desaturase (PDS) and solanesyl diphosphate synthase (SDPS).
- The herbicide is designed to combat resistant weeds such as palmer amaranth and waterhemp.
- FMC expects to begin regulatory submissions for rimisoxafen in key markets starting in 2026.
FMC Corporation Achieves First-Ever Dual Mode of Action Classification
FMC Corporation (NYSE: FMC) announced that the Herbicide Resistance Action Committee (HRAC) has classified rimisoxafen as a dual mode of action herbicide, assigning it to HRAC Groups 12 and 32. According to the company, this represents the first dual mode of action classification in HRAC’s history.
The designation recognizes rimisoxafen’s ability to simultaneously inhibit two distinct biochemical pathways in weeds: phytoene desaturase (PDS) and solanesyl diphosphate synthase (SDPS). FMC stated that targeting both pathways increases the difficulty for weeds to survive and develop resistance.
“HRAC’s historic classification of rimisoxafen validates the breakthrough nature of this technology,” said Seva Rostovtsev, executive vice president and chief technology officer at FMC. “Studies show this molecule delivers control of palmer amaranth and waterhemp, giving farmers an effective solution against weeds that have become resistant to multiple herbicide classes.”
Addressing Herbicide Resistance in Broadacre Crops
Herbicide resistance remains a significant challenge in global agriculture. Palmer amaranth, in particular, has developed resistance to multiple herbicide modes of action, including up to eight different classes in some regions.
FMC indicated that rimisoxafen’s dual mode of action creates a higher barrier to resistance development compared to single mode of action herbicides. The product is designed primarily for use in broadacre crops, including corn, soybean, cereals, pulses, and sunflower, with a focus on controlling troublesome and resistant broadleaf weeds.
The company noted that rimisoxafen was discovered by FMC scientists at the Stine Research Center and represents the third novel herbicide developed for regulatory submission in recent years, following Isoflex® active and Dodhylex™ active.
FMC expects to begin submitting regulatory dossiers for rimisoxafen in key markets starting in 2026, marking the next step toward commercial availability in global crop protection markets.
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