Twist Bioscience Corporation has unveiled its new Whole Genome Sequencing solution, the eWGS, at the Advances in Genome Biology and Technology 2023 General Meeting in Florida. The eWGS is designed to offer researchers low-pass whole genome data and deeper coverage of selected regions in a cost-effective and high-throughput workflow. Twist Bioscience is a leading synthetic biology and genomics company, providing a range of synthetic DNA-based products for industries such as healthcare, agriculture, and academic research.
Twist Bioscience Corporation( NASDAQ: TWST) has announced the technology early access of its enhanced Whole Genome Sequencing (eWGS) solution at the Advances in Genome Biology and Technology 2023 General Meeting in Hollywood, Florida. The eWGS is a novel solution aimed at non-human genomics applications that allow researchers to simultaneously obtain low-pass whole genome data and deeper coverage of selected regions in a high-throughput and cost-effective workflow.
According to CEO and co-founder of Twist Bioscience, Emily M. Leproust, “In agricultural genomics, researchers constantly have to make a tradeoff between cost and insight. With our eWGS solution, researchers now get all the needed information without compromising costs or data, enabling our customers to push new boundaries in trait selection, breeding, and other applications.”
The eWGS workflow starts with a modified Twist 96-plex library preparation kit that prepares 96 samples for sequencing in a single tube. This is followed by single-tube 96-plex enrichment of the library using a customized panel, further supplementing targets that require more coverage. The original and enriched libraries then get combined into a single pool for sequencing. This process can enable a high-throughput workflow and reduce costs using fewer materials and resources.
Twist Bioscience is a leading synthetic biology and genomics company that has developed a DNA synthesis platform to industrialize biology engineering. The company leverages its technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, NGS preparation tools, and antibody libraries for drug discovery and development. Twist Bioscience products are used across many industries, such as healthcare, industrial chemicals, agriculture, and academic research.
In addition to the eWGS technology, Twist will have three posters highlighting its next-generation sequencing (NGS) tools and reference standards available for viewing at the conference. These posters focus on synthetic CNV fragments, RNA exome panels for transcript variants, and methylation controls for methylation level quantification.
Image provided by Twist Bioscience