Key Takeaways
- FMC Corporation submitted the regulatory dossier for rimisoxafen to the U.S. Environmental Protection Agency, marking the first regulatory submission globally for the herbicide active ingredient.
- The U.S. submission covers use on corn, soybean, sunflower, and select pulse crops.
- Rimisoxafen is the first herbicide active ingredient ever classified as a dual mode of action by the Global Herbicide Resistance Action Committee (HRAC), designated under Groups 12 and 32.
- Field testing has shown consistent activity against Palmer amaranth and waterhemp, the most troublesome broadleaf weeds in U.S. soybean production according to a 2025 Weed Science Society of America survey.
- Rimisoxafen is the third novel herbicide active ingredient FMC has advanced to regulatory submission in recent years, following Isoflex active and Dodhylex active.
FMC Corporation Submits Rimisoxafen Dossier to EPA
FMC Corporation, a global agricultural sciences company, announced it has submitted the regulatory dossier for rimisoxafen to the U.S. Environmental Protection Agency, the first regulatory submission globally for the herbicide active ingredient. The U.S. submission covers use on corn, soybean, sunflower, and select pulse crops.
“Filing the first regulatory dossier for rimisoxafen with the EPA represents a significant milestone for FMC,” said Seva Rostovtsev, executive vice president and chief technology officer at FMC. “Years of innovation and scientific discovery have brought us to this point, and we are proud to advance this breakthrough dual mode of action technology through the regulatory process on behalf of growers facing increasingly complex weed resistance challenges.”
A New Dual Mode of Action Herbicide
Discovered at FMC's Stine Research Center and built on more than a decade of biology research and over 1,000 field and greenhouse studies, rimisoxafen is the first herbicide active ingredient ever classified as a dual mode of action by the Global Herbicide Resistance Action Committee (HRAC). Designated under Groups 12 and 32, rimisoxafen inhibits two distinct biochemical pathways in weeds, which helps delay resistance development compared with single mode of action herbicides.
Addressing Herbicide Resistance in U.S. Crops
Herbicide-resistant weeds continue to challenge growers and drive demand for new and underutilized modes of action. A 2025 Weed Science Society of America National Weed Survey ranked Palmer amaranth and waterhemp as the most troublesome broadleaf weeds in U.S. soybean production, and rimisoxafen has demonstrated consistent activity against both in extensive field testing. The U.S. represents a critical market for next-generation weed control, with more than 70 million hectares of corn and soybeans grown annually and growers spending more than $6 billion each year on weed control.
FMC Corporation's Growing R&D Pipeline
Rimisoxafen is the third novel herbicide active ingredient FMC has advanced to regulatory submission in recent years, following Isoflex active and Dodhylex active. Together, the submissions reflect the depth of FMC's research and development pipeline and its focus on advancing next-generation crop protection solutions through the regulatory process.
Next Steps for Global Regulatory Submissions
FMC intends to pursue regulatory submissions for rimisoxafen in additional key geographies and crop segments as part of its global development program. Timing and outcomes are subject to regulatory review and approval in each jurisdiction. Rimisoxafen is not currently registered for sale or use in the United States or any other country, and no offer for sale, sale, or use of the product is permitted prior to receipt of all required regulatory approvals.
5 Comments